Bando-PNRR DM 117
Evaluation of new strategies for preserving explanted organs using ex vivo pig models.
The aim of the project is to create innovative and alternative preservation strategies for explanted organs (lung & cornea) using less hazardous chemicals to alleviate resource constraints in organ transplantation.
The porcine model provides an ideal preclinical platform to study new organ preservation techniques and new therapies for organ repair. Two different ex vivo models will be used:
1) Porcine lungs applying ex vivo lung perfusion (EVLP) technology;
2) Pig corneas collected in slaughterhouses.
Differences in pathophysiological responses to solutions developed by the Society for the preservation of explanted tissues will be explored. The EVLP reperfusion fluid will be analysed using molecular biology techniques, the aim being to identify and analyze molecules related to cellular stress conditions in relation to the tested solution.
The development of new solutions to preserve lungs and corneas can improve the lifespan of explanted organs. This goes hand in hand with efforts to create preclinical animal models for meaningful translational studies.
BSc in Veterinary Biotechnology at the University of Milan UNIMI (2021),
MSc in Veterinary Biotechnology Sciences at the University of Milan UNIMI (2023) with the final evaluation of 110/110 cum laude.
Traineeship period in the Laboratory of Immunology at the University of Veterinary Medicine in Košice (Slovakia) UVMP.
Master’s thesis on the synthesis of a recombinant West Nile Virus protein using yeast as an expression system.
Deep interest in Molecular Biology and Cell cultures.
Publications: Orcid ; IRIS-AIR
Supervisor Prof. Cristina Lecchi
Co-supervisor Prof. Giuliano Ravasio
